A shared interest in the biology of aging brought a chemist, a geneticist and a biologist together to found Proteostasis Therapeutics. In 2006, chemist Jeffery Kelly from The Scripps Research ...

Mitochondria possess a representative member of every stress-inducible chaperone family; thus, providing a paradigm to elucidate the function of the ensemble of molecular chaperones in proteostasis ...

We aim to define molecular functions of cellular factors that facilitate protein homeostasis within the endoplasmic reticulum as well as to uncover small molecules that modulate proteostasis as ...

While aging ultimately causes deterioration in all body systems, the disruption of protein homeostasis, or proteostasis, is ...