RubrYc’s discovery engine takes advantage of recent improvements in machine learning, protein ... and epitope-optimized antibody–drug conjugates, to bispecific antibodies and chimeric antigen ...

Current vaccines and monoclonal antibodies (mAbs) against Plasmodium falciparum, such as RTS,S/AS01 and R21, primarily target the central repeat region of the circumsporozoite protein (CSP) but have ...

The DNA vaccine-derived protein antigen (3) is then degraded by proteosomes into intracellular peptides (4). The vaccine derived-peptide binds MHC class I molecules (5). Peptide antigen/MHC I ...

"Our predictive algorithms are the culmination of 15 years of protein ... epitope mapping not only informs the design of in vitro experiments to target the most relevant regions of the antigen ...

Using a curated dataset of over 650,000 unique human leukocyte antigen (HLA) ligands and cutting-edge AI architectures, MUNIS significantly outperformed existing epitope prediction models.

They used a linker to bind the epitope (section of an antigen) to biotin and then the biotin to a voluminous protein called streptavidin. In this state, the epitope is shielded to the extent that ...

He also researched and developed antigens that could be used to develop immunodiagnostic kits for diagnosing ... He demonstrated that the display of a highly conserved single epitope from HPV L2 ...