Immunologic checkpoint blockade with antibodies against the programmed cell death protein-1 (PD-1) or its ligand (PD-L1) is an effective method for reversing cancer immunosuppression and thereby ...

The study is published in Analytical Chemistry. Programmed cell death protein 1 (PD-1) is an important immunosuppressive molecule in the human immune system, and programmed cell death ligand 1 (PD ...

"There were a number of papers that had suggested a relationship between cell death and oncogenesis, but it was this tie between ced-9 and bcl-2 that really put the nail in the coffin," comments ...

There are several programmed cell death pathways that lead to cellular self-destruction, either for developmental processes, tissue maintenance, or stress responses. These include apoptosis, ...

As the relevant protein structures are often only 1 to 100 nanometers (nm ... which ultimately leads to controlled or ...

Researchers discovered that gut microbiota-derived hexa-acylated LPS enhances the effectiveness of anti-PD-1 cancer ...

Researchers reveal that gut microbiota influence the effectiveness of immune checkpoint inhibitors (ICIs) in cancer treatment ...

Tislelizumab is BeiGene’s programmed cell death protein 1 (PD-1) checkpoint inhibitor and Anktiva is an interleukin-15 (IL-15) superagonist from ImmunityBio. The trial aims to confirm the safety and ...

Researchers identified two anoikis-related genes linked with CTEPH, and that may serve as diagnostic biomarkers or treatment ...

Danés, principal investigator of the Cancer and Stem Cell Biology Lab at the Champalimaud Foundation, in Lisbon, has shown ...