Do "prions" exist? The word "prion" is used ... a protein molecule folded in an abnormal way can alter the folding of another protein molecule and thereby change its biological properties.

Protein folding is the process by which proteins achieve their mature functional (native) tertiary structure, and often begins co-translationally. Protein folding requires chaperones and often ...

Protein folding has been an ongoing problem for researchers since 1972. Christian Anfinsen speculated in his Nobel Prize acceptance speech in that year that the three-dimensional structure of a ...

How proteins achieve their correct shape is the subject of this special Focus. For those who practice the traditional Japanese art of paper folding, or origami, a sheet of paper can be used to ...

[3,4,5,6,7,8,9] They appear to be constituted by proteins ... in folding abnormalities, and that different conformations have been detected by Western blot analysis in prion proteins.

SOME diseases are so devastating that survival is virtually impossible – with fatality rates hitting 100 per cent. Thankfully, due to modern medicine, they’re incredibly rare. The few that ...

The biomarker development pipeline is generally composed of three stages: biomarker discovery, verification and clinical validation (Figure 1). The process begins with biomarker discovery where ...

This module examines the mechanisms employed by proteins to adopt unique functional folds and explores the causes and consequences of mis-folding, with a particular reference to neurodegenerative ...

Prion diseases, a group of rare brain disorders ... These conditions are caused by proteins in the brain folding incorrectly, ...