In the human placenta, there are placental villi, and the surface of the villi consists of syncytiotrophoblast, also called barrier cells, that serve as the main barrier against foreign substances.
OBJECTIVE: In vitro and animal experiments suggest that P-glycoprotein forms a functional barrier between maternal and fetal blood circulation in the placenta, thus protecting the fetus from ...
A Cell study published last week showed the antibodies created by RNA vaccines for HIV and Zika virus can cross the placental barrier and inoculate baby rabbits. The authors noted a major route for ...
which can lead to interruptions in gas exchange across the placental barrier. Occlusion of one or more of the vessels in the umbilical cord can impede circulation to and from the fetus.
P-gp is expressed in normal tissues particularly at the sites of absorption (gut) and excretion (kidney and liver) and on blood tissue barriers (brain, testes, and placenta). Its vectorial ...