In gram-negative bacteria, the most common mechanism of resistance is the hydrolysis, or breaking apart, of the antibiotics by enzymes referred to as the beta-lactamases. There are two broad classes ...

The β-lactamase (or lactamases) of gram-negative bacilli appears to be an important factor in their resistance to penicillins and cephalosporins, and may be a factor in the synergistic ...

is one of the major mechanisms of antibiotic resistance. Plasmid borne genes encoding modifying enzymes such as beta-lactamases, that confer resistance to penicillins and related antibiotics, or, more ...

Gram-negative bacteria have three major resistance mechanisms to carbapenem antibiotics: porin channel mutations to prevent cell entry, efflux pumps to expel antibiotics and beta-lactamase enzymes ...

including those that work in combination with beta-lactamase production. We are also studying permeability mechanisms of aminoglycoside resistance in E. coli and we are using genomic surveillance to ...

AbbVie has claimed FDA approval for Emblaveo, a new antibiotic product to treat complicated intra-abdominal infections (cIAI) ...

AbbVie has announced that the US Food and Drug Administration (FDA) has approved its Pfizer-partnered Emblaveo ...

Among the major problems faced in medicine, resistance to antibiotics is regarded as a singular challenge. The primary focus of our laboratory is to understand the genetic and amino acid sequence ...

These antibiotic-resistant "superbugs" directly caused ... Bacteria often produce enzymes, like beta-lactamase, to destroy antibiotics. Enmetazobactam binds tightly to those enzymes, neutralising ...

Research presented at the World Microbe Forum (online, 20–24 June 2021) has detailed the use of native mass spectrometry in the evaluation of how potential inhibitors work on antibiotic-resistant ...