A comprehensive toolkit for spatial biology Orr’s team follows protein expression across ... It's another step towards understanding tau pathogenesis and cellular senescence, and their links ...

Furthermore, NFTs may also contribute to the disease progression by effectively sequestering more tau and other proteins, and thereby reinforcing and amplifying the loss of normal tau function.

There is a potential link between Alzheimer's disease and the herpes simplex virus-1 (HSV-1), which is a common cause for ...

contributing to the pathogenesis of Alzheimer's disease, frontotemporal dementia, and other tauopathies. Name: Microtubule-associated protein tau Target Synonym: MAPT, MTBT1, Paired helical ...

Currently, there is ongoing discussion on the precise mechanism of AD pathogenesis ... the β-amyloid waterfall theory, and the Tau protein theory. The majority of patients diagnosed with ...

This manuscript describes the identification and characterization of 12 specific phosphomimetic mutations in the recombinant full-length human tau protein that trigger tau to form fibrils. This ...

The current human tissue-based study provides convincing evidence correlating hippocampal expressions of RNA guanine-rich G-quadruplexes with aging and with Alzheimer's Disease presence and severity.

For example, when expressed in the Drosophila brain, Tau protein—which forms neurofibrillary tangle pathology in AD—causes ... revealing a number of molecular pathways with roles in AD pathogenesis ...

Important subside pour mieux comprendre la maladie d'Alzheimer. Aurélien Lathuilière, a neurologist at the HUG Memory Centre and research associate in the Departments of Cell Ph ...

Past studies found that patients diagnosed with AD, as well as some other neurodegenerative disorders, exhibit an abnormal accumulation of tau protein in their neurons. Tau protein is a ...