One of these is called the Polycomb Repressive Complex 2 (PRC2), a collection of proteins that can modify histones to silence ...

ORIC Pharmaceuticals is concurrently developing ORIC-944, a molecule that targets the same PRC2 complex as mevrometostat but focuses on the EED subunit. Pfizer's confidence in mevrometostat is ...

The critical role of EZH2, an essential epigenetic regulator, in cancer progression and treatment is underscored in this new review article published in Genes & Diseases.