Researchers uncover focal adhesions as subcellular signaling hubs in PI3K-AKT pathway
AKT signaling pathway is one of the most critical and extensively investigated signaling pathways. It is the central ...
调节肿瘤发生和肝转移！北京大学崔一民教授团队：结直肠癌的靶向 ...
【导读】由于缺乏有效的治疗手段，肝转移是结直肠癌（CRC）患者死亡的主要原因。 11月5日，北京大学崔一民教授研究团队在期刊《Advanced Science》上发表了题为“Targeting SLITRK4 Restrains ...
The American Journal of Managed Care5 年
The PI3K Pathway: The Benefits of Dual Inhibition in Follicular Lymphoma
38 Nevertheless, studies using proteomic analysis have confirmed AKT phosphorylation in FL samples, which is indicative of PI3K pathway activation. 39,40,42,43 Additional evidence for the ...
emjreviews.com7 天
PI3K Pathway Identified as Key in SSc Skin Fibrosis: ACR2024
Discover how cutting-edge research unveiled at ACR Convergence 2024 highlights macrophage-fibroblast interactions and the ...
Medscape6 天
Targeting Pathways Downstream of KRAS in Lung Adenocarcinoma
Murine Kras-driven lung cancer models have confirmed the key requirements for RAF, PI3K and RAL-GEF in vivo. Co-opted pathways required by oncogenic KRAS in order to sustain lung tumorigenesis ...
AZoLifeSciences on MSN9 天
Caterpillar Fungus Compound Blocks Cancer Growth Signals Within 30 Minutes
Cordycepin, derived from fungi, shows promise in cancer therapy by inhibiting growth factor signaling pathways critical for ...
pharmaphorum1 年
AZ first to AKT finish line, but FDA clears narrow label
The company’s head of oncology, Dave Fredrickson, said the approval of Truqap “reinforces the important role of the PI3K/AKT pathway in HR-positive breast cancer and the critical need to test ...