Expert Rev Ophthalmol. 2013;8(6):527-537. Protein kinase C-mediated contraction of RPE cells is stopped by an anti-PDGF antibody. Unfortunately, blocking PDGF is ineffective at suppressing PVR in ...
This review discusses the biology of VEGF and PDGF and current preclinical and ... In conjunction, weaknesses in Bruch's membrane facilitate extravasation of choroidal vessels into the subretinal ...