目前国内免疫药物主要有PD-1单抗和PD-L1单抗两大类。大家可能觉得，这两种药物其实是针对同一免疫通路的两个端点，机制上似乎是一致的。其实不然，两者之间存在着一定的区别，无论是在药物设计、作用机制到临床疗效，甚至耐药处理上都有不同之处。今天就全面给 ...

【导读】免疫检查点阻断（ICB）疗法已成为多种晚期癌症的新治疗范式，但由于低响应率，其广泛的临床应用受到了阻碍。在这项研究中，团队采用了一种基于肽的、仿生的、自组装策略，制造了一种纳米颗粒TPM1，用于结合肿瘤细胞表面的PD-L1。2024年11月9 ...

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An expert explained how a patient’s own T cells can be extracted, manufactured and infused back into the body as a treatment ...