p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...

The fragile structure of p53 gene reveals why this crucial cancer defense is so easily compromised, shedding light on the genetic Achilles' heel of many tumors. In a recent perspective published in ...

In conclusion, the study highlights how p53's evolutionary structure makes it particularly vulnerable to mutations that impair its tumor-suppressive function. This vulnerability is not merely a ...

Molecular dynamics simulations calculate the structure of p53m and its binding interfaces with p53-R175H and CRBN (a), and PAGE electrophoresis confirms the successful connection between p53m-DA ...