First, despite its superficially inert appearance, bone is rapidly and continuously remodeled at a high rate by bone-forming osteoblasts and bone-resorbing osteoclasts. The latter differentiate ...

While several scientific reports have revealed the distinct regulatory mechanisms of osteoclast and osteoblast differentiation, little is known about the common factors that influence the ...

The discovery of a family with sequence similarity 102 member A (Fam102a) protein as a novel bone remodeling factor that regulates both osteoclast and osteoblast differentiation can aid the ...

In just 3 years, striking new advances have been made in understanding the molecular mechanisms that govern the crosstalk between osteoblasts/stromal cells and hemopoietic osteoclast precursor ...

While several scientific reports have revealed the distinct regulatory mechanisms of osteoclast and osteoblast differentiation, little is known about the common factors that influence the ...

While several scientific reports have revealed the distinct regulatory mechanisms of osteoclast and osteoblast differentiation, little is known about the common factors that influence the ...

Bone dynamics depend on two associated cell types: osteoblasts, which are responsible for bone formation, and osteoclasts, which are responsible for bone resorption. Until now, it has not been ...

Regulation of osteoclastogenesis by factors from osteoblasts/stromal cells interacting with receptors on hematopoietic osteoclast precursor cells. RANK-L: receptor activator of NF-kappaB ligand ...

The imbalance occurs between osteoblasts, responsible for bone formation, and osteoclasts, which break down bone tissue. This disrupted process results in weakened bones and increased ...