[2] Tenofovir was approved by the Food and Drug Administration (FDA) in October 2001 through an accelerated approval process; it is the first nucleotide analogue reverse-transcriptase inhibitor ...

Here we show a unique and previously unrecognized mechanism of drug action in which Et743 subverts normal nucleotide excision repair (NER) by generating lethal DNA breaks during by transcription ...

The application of pharmacogenetics in identifying single nucleotide polymorphisms (SNPs) in DNA sequences that cause clinically significant alterations in drug-metabolizing enzyme activities is ...

The development of new machine learning tools like Alphafold and Rfdiffusion has allowed scientists to predict the structure ...

Several recent Imhotex Ltd. patents describe novel analogues of muramyl dipeptide (MDP), desmuramylpeptides (DMPs), acting as nucleotide-binding oligomerization domain-containing protein 2 (NOD2) ...