Many of the nucleoside antibiotics exhibit their activity only after conversion into their nucleotide form (mono- or triphosphate) once inside the cell. A number of nucleoside analogues which were ...

Each nucleoside triphosphate is made up of three phosphates ... the free energy needed to drive the incorporation of each nucleotide into the growing DNA chain. The reaction shown on the bottom ...

Clin Drug Invest. 2007;27(8):509-531. Because of its poor tolerability, regimen complexity and drug-interaction potential relative to other new NRTIs, use of didanosine has decreased over the last ...

Generally, the dual NRTI backbone treatment of combination with a non-NRTI (NNRTI) or protease inhibitor (PI) should comprise a cytidine analogue (lamivudine, emtricitabine) and a thymidine ...

Or you may be offered a combination that consists of two drugs in one pill, accompanied by a third drug in another pill. Nucleoside reverse transcriptase inhibitors (NRTIs), and nucleotide reverse ...

This article was originally published with the title “ The Nucleotide Sequence of a Nucleic Acid ” in Scientific American Magazine Vol. 214 No. 2 (February 1966), p. 30 doi:10.1038 ...

2009.06.021. Pizzagalli, A. et al. DNA polymerase I gene of Saccharomyces cerevisiae: nucleotide sequence, mapping of a temperature-sensitive mutation, and protein homology with other DNA polymerases.

ATP, an acronym for adenosine triphosphate, provides energy to our cells, thereby aiding in the execution of physical activities. During workout sessions, our bodies deplete ATP, therefore ...

Inosine is a nucleoside that occurs naturally in transfer RNAs (tRNAs) and is essential for proper RNA translation. It is commonly found at the wobble position of anticodons, allowing for greater ...

ATP works by losing the endmost phosphate group when instructed to do so by an enzyme. This reaction releases a lot of energy, which the organism can then use to build proteins, contact muscles, etc.

The P-loop phosphotransferase fold of the kinase is embellished by a unique “G-loop” element that accounts for guanine nucleotide specificity. Mutations of amino acids that contact the guanine ...

Currently we are interested in the chemical synthesis of 5'-triphosphates of base-modified, nucleoside analogues that have altered base pairing specificities. We are studying the incorporation of ...