Members of the nuclear receptor superfamily of transcription factors have important roles in modulating the responses of macrophages, microglia and lymphocytes to pro-inflammatory signalling ...

此外，此前研究发现缺失 NR2F6 可增强 T 细胞的抗肿瘤反应，尤其是在免疫检查点抑制期间。本研究进一步表明，在 NK 细胞中缺失 NR2F6 对于缺乏有效 T 细胞表位或下调 MHC-I 表达以逃避免疫监视的肿瘤可能具有重要意义，为联合治疗干预提供了潜在途径。然而，NKp46 表达增强在自身免疫性疾病如系统性红斑狼疮（SLE）中的作用仍有待进一步研究，需要深入探讨 NK 细胞上 NKp46 ...

We investigated the expressions of hepatocyte transporters and nuclear receptors comprehensively in patients with early-stage and late-stage BA. These data provide evidence of how human liver ...

Donald Patrick McDonnell, Ph.D., has been awarded the Endocrine Society’s John D. Baxter Prize for Entrepreneurship for discovering hormone therapies for treating breast and prostate cancer, the ...

Work at the University of Florida has led to the identification of nuclear receptor subfamily 1 group D member 1 (Rev-erbA-α) antagonists reported to be useful for the treatment of cancer, sarcopenia ...

Live webcasts of these presentations will be available in the Events and Presentations section of Olema’s investor relations website at ir.olema.com. The webcasts will be archived for at least 30 days ...