Sensory pathways in Drosophila to detect and avoid 2MT are shown. Flies escape from 2MT through olfactory, taste, and nociceptive sensory pathways. This study identified that TRPA1 expressed in ...

transferring information about the intensity and duration of the painful stimulus. Persistent pain Pain that persists long after or in the absence of injury can result from the misfiring of the normal ...

Box 1. Glossary. Aβ-fibers: large-myelinated nerve afferents or pathways that convey non-nociceptive input (e.g., tactile sensation) Aδ-fibers: small-myelinated nerve afferents or pathways ...

Therefore, drug targets that act in the brain, specifically on the central component of the trigeminovascular system, the TCC, would seem to be ideally placed to modulate this nociceptive pathway ...