Therefore, drug targets that act in the brain, specifically on the central component of the trigeminovascular system, the TCC, would seem to be ideally placed to modulate this nociceptive pathway ...

in an olfactory pathway, and direct contact with 2MT activates TRPA1 in taste and nociceptive pathways. This resulted in apparent avoidance of the chemical source by male flies and avoidance of ...

Sensory pathways in Drosophila to detect and avoid 2MT are shown. Flies escape from 2MT through olfactory, taste, and nociceptive sensory pathways. This study identified that TRPA1 expressed in ...

Box 1. Glossary. Aβ-fibers: large-myelinated nerve afferents or pathways that convey non-nociceptive input (e.g., tactile sensation) Aδ-fibers: small-myelinated nerve afferents or pathways ...

Gastric pain has limited treatment options and the nociceptive ascending pathway remains largely unclear. Here, the authors identify a glutamatergic tetra-synaptic NTS–LPB–PVT–PL circuit ...

More recently, research has found evidence that viruses can activate nociceptive neurons by expressing certain receptors, such as STING. We decided to explore this pathway," said Cunha ...