The Farese & Walther laboratory investigates cellular lipid and energy metabolism, in particular the mechanisms and physiology of neutral lipid synthesis and storage in lipid droplets. More broadly ...

an ionizable cationic lipid (1,2-dilinoleyloxy-3-dimethylaminopropane), a neutral helper lipid, including Chol and fusogenic lipids, and a PEG lipid (Table 2). In SNALPs, the backbone-modified ...

In the bloodstream, ionizable lipids stay neutral, preventing toxicity. But once inside the target cell, they become positively charged, triggering the release of the mRNA payload.