Third, multi-domain proteins are relatively large, which increases the difficulty of using NMR to determine their structure. A general and powerful strategy that simplifies the analysis of complex ...

The acquisition of standard NMR spectra takes from a few minutes (1D spectra) to 3/4 days (3D or 4D spectra) for each experiment. A full set of experiments for protein structure determination usually ...

Structure determination by NMR typically requires a protein concentration of 0.5 mM or greater, stable for several days at the desired temperature, usually 20-40 o C. Proteins and peptides should be ...

My research concentrates on protein structure and function, mainly by means of NMR, and is described in more detail below. I also teach NMR and protein structure, signalling, membranes and molecular ...

Nuclear magnetic resonance (NMR) spectroscopy allows scientists to probe an intrinsically disordered protein’s structure and dynamics as it wiggles around in solution. NMR spectrometers use strong ...

Accurate protein structure prediction is critical for decoding ... nuclear magnetic resonance (NMR), and cryo-electron ...

This work includes using in cell NMR, a technique to study the structure and dynamics of proteins within living cells. I currently study intrinsically disordered proteins using solution NMR. Proteins ...