These simulations suggest that the time window for action potential amplification will depend on both the AMPA/NMDA ratio at the synapse, and the degree of synchrony in the synaptic input.

Directly after re-exposure to these cues, AMPA receptor subunits GluR2 and GluR3 and NMDA receptor subtype 2B were downregulated in synaptic membranes of the medial prefrontal cortex, and clathrin ...