9 A number of overlapping inherited non-dystrophic myotonia syndromes result from mutations to the gene encoding the voltage-gated sodium channel type IV alpha subunit (SCN4A). Paradoxical ...

Gamstorp specifically excluded clinical myotonia from her syndrome ... the chloride 91 milliequiv., and the sodium 145 milliequiv. per liter. The total protein was 7.4 gm. per 100 ml., ...

Using a unification of molecular and biophysical approaches, our research leads to a more complete understanding of the structure-function relationships within the sodium channel molecule. In so doing ...