The EGFR pathway has an important role in modulating ... Given the focus on personalized cancer care in the context of KRAS mutation status in colorectal cancer, the clinical community will ...

[28] Two pathways thought to be relevant in the ... intracellular molecular effectors downstream to EGFR; and (iv) EGFR gene mutations or loss of the target. EGFR TKI plus EGFR MAb, multi-ErbB ...

Alternative RTK pathways that are activated following EGFR inhibition is another area ... and as yet undiscovered mutations. Advancing our knowledge of specific cellular and molecular mechanisms ...

A groundbreaking study led by USC Assistant Professor of Computer Science Ruishan Liu has uncovered how specific genetic ...

The research uncovers key genetic mutations that affect cancer treatment responses and develops a predictive tool for ...

J&J is trying to supplant AstraZeneca's blockbuster Tagrisso, a once-daily pill that has transformed the treatment of non-small cell lung cancer with EGFR mutations. It remains to be seen how many ...