The Lower Mississippi Valley is more than just a distinct geographical region of the United States; it was central to the outcome of the Civil War and the destruction of slavery in the American South.
Although slavery is illegal in every country in the modern world, it still exists, and even on the narrowest definition of slavery it's likely that there are far more slaves now than there were ...
The westward expansion carried slavery down into the Southwest, into Mississippi, Alabama, crossing the Mississippi River into Louisiana. Finally, by the 1840's, it was pouring into Texas.