在本研究中对alphabaculoviruses中报告的bac-miRs以及其他先前发表的综合性研究的分析提供了有用的见解，以指导未来在杆状病毒基因组中表达miRNA分子的新型非编码基因的预测。为了进一步增强这一领域的研究，值得注意的是，存在许多数据 ...

结论：这项研究揭示了在肿瘤中广泛积累的异常 miRNA 异构体，并开发了一种通过编辑和修复有缺陷的 miRNA 来实现的植物 RDR1 介导的抗肿瘤策略。这些发现为癌症治疗提供了新的视角，即通过利用植物免疫蛋白来修复肿瘤中的 miRNA 缺陷，从而抑制肿瘤生长。

而合理利用miRNA的作用机制，可以靶向抑制细胞增殖，来治疗癌症[15]。同时，人体内对于有着缺陷的基因，具有自我修复机制。这个机制，同样需要miRNA的参与。miRNA通过调控DNA的自我修复，同样有利于癌症的治疗[16]。

B efore the committee that awards the Nobel Prize for physiology or medicine made its announcement on October 7th, the ...

【导读】染色体外环状DNA （extracchromosomal circular DNA, eccDNAs）是由环状和可移动DNA分子组成的不同基因组实体，但其在乳腺癌（breast cancer， ...

The Nobel Prize in Physiology or Medicine 2024 has been awarded to US scientists Victor Ambros and Gary Ruvkun for their work ...

Yang, A. (2024) Virus-Encoded MicroRNAs Reveal How Ranavirus Interacts with Amphibian Immune Defense. Journal of Biomedical ...

Drs. Gary Ruvkun and Victor Ambros have been honored for their critical work in discovering the essential role of very small ...

They showed that shutting down a damaged copy of a gene called a microRNA (miRNA) enabled ... Novel Genome Editing Approach Restores Hearing in Adult Preclinical Models With Genetic Deafness July ...

Automated Slide multiplex imaging (Cell DIVE) and staining (BAB200 & Leica BOND RXm) High content image analysis using dedicated software and analysis workstations (Developer Toolbox, INCarta and HALO ...