Huang's group had previously found that mouse neurons producing human APOE4 release molecular signals that activate microglia. This time, they used the new mouse model to probe in more detail the ...

To investigate, Kaji and colleagues hunted them down in the ApoE-Halo/5xFAD mouse brain with confocal microscopy and three-dimensional imaging. In addition to the usual large extracellular plaques, ...

Campus Chemical Instrument Center, Mass Spectrometry & Proteomics Facility, The Ohio State University, Columbus, USA ...

What if fighting the onset of dementia was as simple as a few sniffs? Researchers at Texas A&M have discovered a new therapy ...

But when APOE4 is expressed, microglia seem to start to cause inflammation, and misfolded proteins to form in the brain, ...

Huang's group previously found that mouse neurons producing human APOE4 release molecular signals that activate microglia. This time, they used the new mouse model to probe in more detail the ...

In a new study from Texas A & M University College of Medicine, researchers have used a nasal spray to target microglia and ...