Melphalan is an alkylating agent with cytotoxic action that appears to be related to the extent of its interstrand cross-linking with DNA, probably by binding at the N7 position of guanine.

Melphalan 200 mg/m 2 vs melphalan 100 mg/m 2 in newly diagnosed myeloma patients: a prospective multicenter phase 3 study. Blood 115 , 1873–1879 (2010). Article CAS PubMed Google Scholar ...

NG25 reduce viability of CD138+ cells from patients, alone and in combination with melphalan. (A) CD138+ cells from 10 individual donors were treated with NG25 before cell viability was measured.