We are studying the mechanism and regulation of meiotic recombination in mouse. Portions of this work are part of a longstanding collaboration with Maria Jasin’s lab in the Developmental Biology ...

Unlike its DNA repair role in somatic cells, homologous recombination has a distinct role in meiosis in ensuring proper chromosome segregation. In yeast, an early step of the meiotic program is the ...

Enlarging the focus to include organisms with novel meiotic formats would help to ... how do homologous sequences get together for recombination? Nature Rev. Genet. 9, 27–37 (2008).

How is the same process responsible for genetic recombination and diversity also ... players in meiosis from biochemical analyses of meiotic chromosomes and from genetic studies of meiosis ...

In Meiosis I homologous chromosomes separate, which requires pairing, synapsis, and recombination. In Meiosis II sister chromatids segregate from each other similarly to mitosis. Meiotic events must ...