We are studying the mechanism and regulation of meiotic recombination in mouse. Portions of this work are part of a longstanding collaboration with Maria Jasin’s lab in the Developmental Biology ...

Unlike its DNA repair role in somatic cells, homologous recombination has a distinct role in meiosis in ensuring proper chromosome segregation. In yeast, an early step of the meiotic program is the ...

Enlarging the focus to include organisms with novel meiotic formats would help to ... how do homologous sequences get together for recombination? Nature Rev. Genet. 9, 27–37 (2008).

Aberrant segregation was first clearly noted in the 1950s in genetic studies of certain fungi that allow direct examination of their four haploid products of meiosis. Normally in these fungi, a ...

In Meiosis I homologous chromosomes separate, which requires pairing, synapsis, and recombination. In Meiosis II sister chromatids segregate from each other similarly to mitosis. Meiotic events must ...