The question of putative mechanisms of action continues to haunt psychopharmacology. Put simply, we know these drugs work, but we have very little idea how. We make guesses based on the ...

André). Metronomic chemotherapy is based on the chronic administration of chemotherapeutic agents at relatively low, minimally toxic doses, and with no prolonged drug-free breaks Metronomic ...

Although the precise mechanism of action of bevacizumab is unclear ... the addition of bevacizumab to conventional chemotherapy has demonstrated some clinical benefit. Consequently, this drug ...

Importantly, this research establishes nanopore approaches as a powerful single-molecule technique for exploring the molecular mechanisms of protein action.

which includes surgery followed by a combination of aggressive chemotherapy and radiation. In response, multiple Feinberg investigators have sought to identify new mechanisms that contribute to ...

Inside every cell, a network of tiny filaments, called the microtubule cytoskeleton, helps maintain the cell's shape, allows ...

The combination of immune checkpoint inhibitors (ICIs) with chemotherapy has revolutionized cancer immunotherapy, significantly improving patient outcomes across various malignancies. ICIs, by ...

Noah M. Merin, MD, PhD, discusses the mechanisms of action and sequencing of oral therapies for chronic graft-vs-host disease ...

In clinical trials, SA13CA has shown significant efficacy and durable response rates in patients with relapsed or refractory CTCL and PTCL. Additionally, in patients with ALL, SA13CA has demonstrated ...

A research team led by Prof. Zhou Rongbin from the University of Science and Technology of China (USTC) discovered the ...

Ibrilatazar is an oral drug with a novel mechanism of action that induces autophagy through the induction ... when administered in combination with chemotherapy and subsequently as maintenance therapy ...

SELLAS Life Sciences Group, Inc. (SLS), a late-stage clinical biopharmaceutical company, Tuesday announced that the U.S. Food and ...