A University of California, Riverside team of scientists has used a novel approach to identify protein degraders that target ...

Macrophages are a type of white blood cell ... The title of the paper is “Targeted Degradation of Pin1 by Protein ...

In drug discovery, targeted protein degradation is a method that selectively eliminates disease-causing ... They also wanted ...

More information: Bone marrow macrophage derived GPNMB protein binds to orphan receptor GPR39 and plays a critical role in cardiac repair, Nature Cardiovascular Research (2024).

Background Peritoneal metastasis is the most common metastasis pattern of gastric cancer. Patients with gastric cancer ...

Scientists have identified the protein GPNMB as a critical regulator ... they demonstrate that bone marrow-derived immune cells called macrophages secrete GPNMB, which binds to the receptor ...

when these large protein complexes – called inflammasomes – were discovered. These inflammasomes, when assembled inside the ...

Trials with mice in whom the researchers implanted human glioblastoma cells have already shown that the treatment is very ...

Department of Physiology, Harold Hamm Diabetes Center, The University of Oklahoma Health Science Center, Oklahoma City, United States ...