For example, MDM2 binds to TP53 mRNA ... The biological effects of p53 pathway variants at the molecular level in primary cells or in vivo still need to be determined. The design of genetically ...

【导读】结直肠癌(CRC)是全球癌症相关死亡率的第二大原因，而p53作为一种被广泛认可的肿瘤抑制因子，促进了CRC的发展。USP36属于去泛素化酶家族，参与多种癌症的进展。然而，在结直肠癌中USP36调控p53信号通路的潜在分子机制尚不清楚。9月29 ...

Malfunction of the p53 pathway is an almost universal hallmark ... such as gene amplification of key negative regulators of p53, MDM2 and MDM4. Germline TP53 mutations are found in individuals ...

These two pivotal studies will be multicenter, open-label, randomized, registrational Phase III studies: first one is to evaluate the efficacy and safety of APG-2449 versus platinum-based ...

The orally-available MDM2-p53 agonist is designed to restore the ... while its signalling pathway is disrupted in the other half. Brigimadlin (also known as BI 907828) is a small molecule that ...

as well as candidates aimed at IAP and MDM2-p53 pathways, and next-generation TKIs. Ascentage Pharma is also the only company ...

The pathways diagram (Academic career pathway diagram (PDF, 89kB)) shows the three pathways and roles, including accepted progression and promotion routes.‌‌ The clinical career pathways are sub-sets, ...

In consultation with your academic advisor - utilize the worksheet below to assist you in selecting appropriate and valid paths while navigating the Path Finder tool. If you need an accessible version ...

The MSc Education (Open Pathway) allows you to design your own programme of study based on your areas of interest, rather than choosing one subject area from our specialist pathways. Units can be ...

Through the Pathways you will develop a deep knowledge base in a chosen topic and learn how different disciplines approach a similar line of study. Take ownership of your education by choosing topics ...