Disappearance of SUMO-modified Mdm2, which is observed upon radiation, may thus be a prerequisite for DNA-damage-induced accumulation of p53. Figure 2: Destructive pathways: SUMOylation of Mdm2 ...

For example, MDM2 binds to TP53 mRNA ... The biological effects of p53 pathway variants at the molecular level in primary cells or in vivo still need to be determined. The design of genetically ...

Malfunction of the p53 pathway is an almost universal hallmark ... such as gene amplification of key negative regulators of p53, MDM2 and MDM4. Germline TP53 mutations are found in individuals ...