Objective: Newborns are highly susceptible to bacterial sepsis. Mannan-binding lectin (MBL), M-, L- and H-ficolin recognize microorganisms and activate the complement system via MBL-associated ...
The research team created a series of GnT-IVa and GnT-IVb mutants that impaired only the lectin-binding activity of both glycosylation enzymes to determine whether or not lectin binding was ...