It is the original example of a group of diseases, known as the "transmissible spongiform encephalopathies" (TSE), sometimes known as the "prion" diseases. The diseases include Creutzfeldt Jakob ...

Prion diseases, a group of rare brain disorders, not only puzzle the world’s leading scientists but also progress swiftly ...

Interestingly, the extended PMCA yielded novel forms of misfolded prions that caused new disease phenotypes. When injected into wild-type hamsters, the PMCA-generated hampster PrP Sc caused ...

Prions, the causative agents of transmissible spongiform encephalopathies, appear to consist entirely of PrP Sc, an orderly aggregated, β sheet–rich isoform of a ubiquitous membrane protein ...

The first detailed structure of an infectious prion that causes chronic wasting disease, or CWD, reveals features that could help guide vaccine development or explain why the illness hasn’t yet ...