San Francisco 49ers left tackle Trent Williams, who has missed his team's last four games with an ankle injury, may sit the remainder of the season.

With Trent Williams still battling through an ankle injury, the 49ers may have no choice but to cut his season short.

The 49ers will have to start their fourth different running back this Sunday against the Miami Dolphins. That's because rookie running back Isaac Guerendo is likely to miss Sunday's game with a hamstring injury he suffered this past Thursday night.