Now ketamine, a glutamatergic NMDA receptor antagonist, may provide a mechanism that could link these pathways. Figure 1: A schematic of how ketamine may lead to an overall excitation in the cortex.

Like a lock and key, ketamine binds to the brain via N-methyl-D-aspartate (NMDA) receptors. NMDA receptors are all over the brain and are essential in maintaining consciousness. The study came ...

These images demonstrate the different binding sites in NMDA receptors that the UB team has discovered are responsible for ketamine’s distinct clinical effects, as an anesthetic at high doses ...

The pathophysiology of depression remains largely unknown and there is a significant need for development of novel and more efficacious antidepressant treatments.Ketamine is a non-competitive channel ...

Ketamine has long been seen as a potential ... It works on the N-methyl-D-aspartate (NMDA) receptor, an ionotropic glutamate receptor in the brain, and is used alongside a newly prescribed oral ...

Ketamine affects key switches in the brain called NMDA receptors. Like serotonin receptors, those for NMDA play an important role in our mood and help keep our emotions in check. But NMDA ...

Ketamine acts as an NMDA receptor antagonist, which leads to downstream activation of the mTOR pathway and increased synaptogenesis. Ketamine Traditional antidepressants can take weeks to improve ...

Ketamine antagonizes the effect of the excitatory neurotransmitter N-methyl-D-aspartate (NMDA) on NMDA receptors, and opioid agonists stimulate opioid receptors. Adult patients often prefer that ...