Rett syndrome, a severe delayed-onset autism spectrum disorder, affects at least 1 in every 10,000 females. The syndrome is caused by a mutation of the MECP2 gene, which is located on the X ...

In 1999, mutations in the MECP2 gene were identified as the primary cause of Rett syndrome. MECP2 mutations can be found in 70% to 80% of all clinically defined Rett syndrome cases; in classic ...