Paneth cells also contribute at the base of small intestinal crypts to the primary niche for intestinal stem cells. Microfold cells or M cells sample antigens from the lumen and deliver them to ...

requiring constant and precise regulation of intestinal stem cells (ISCs) to sustain the production of new absorptive enterocytes and secretory cells, including Paneth, goblet, tuft, and ...

Paneth cells seem to be central for the development of small intestinal CD. Antimicrobial defensins, especially Paneth cell defensins, regulate the composition of the bacterial flora. Chemokines ...

A new study published in Cell shows that a dysregulated response to endoplasmic reticulum (ER) stress can lead to organ-specific inflammation, and that hypomorphic variants of X-box-binding ...

Studies of two different mouse strains deficient in the autophagy-related gene product Atg16L1 now show that autophagy is important in regulating the secretory function of Paneth cells and the ...

During homeostasis, the ISC niche exists in the crypt together with differentiated cells (e.g., lysozyme producing Paneth cells in the small intestine) and stromal cells at the underlying mesenchyme.