为解决免疫治疗中多数患者无响应的难题，韩国延世大学医学院的研究人员开展一碳代谢（1CM）在肿瘤免疫微环境作用的研究，发现 1CM 是增殖性中间耗竭 T 细胞（Texint）的代谢标志。该成果为免疫治疗提供新思路，值得科研人员一读。

Immunotherapy, which uses programmed immune cells to selectively destroy cancer cells, has transformed cancer treatment.

When a tumor develops, it creates a structure around itself called the tumor stroma, within which blood and lymphatic vessels ...

Researchers determine a complex immune infiltrate pattern based on a newly constructed immune map developed using pancreatic ...

黑色素瘤和肺部样本分析表明，线粒体作为细胞的能量引擎，可以从癌细胞跳到T细胞。这些转移的线粒体在其DNA中携带功能错误，干扰了T细胞的能量产生和功能过程。线粒体对包括T细胞在内的细胞提供能量至关重要，而且T细胞在很大程度上依赖于能量产生来对抗癌症。

Researchers have identified the transfer of mitochondria with mutated DNA from cancer cells to immune cells as a key ...

Within the immune system, interleukin-15 (IL-15) plays a relevant role by boosting the number of cytotoxic T cells and NK cells, the major drivers of anticancer immune response. Researchers from Sotio ...

Engineered immune cells called CAR-T cells are used in the treatment of cancer. Researchers from Uppsala University have now ...

In the ongoing battle against triple negative breast cancer, Vanderbilt researchers have uncovered a promising non-invasive ...

When blood cancer cells break through the bone and multiply, tumor cells become dangerously diverse and the immune response in the region changes, researchers report. The detailed insights into cancer ...

The immune system plays a key role in detecting and destroying cancer cells. Cancer immunotherapy works by programming immune ...