IL-2 and IL-15 receptor complexes share the β and γ chains, and the γ chain is used by IL-4, IL-7, IL-9 and IL-21. IL-2 attaches to only IL-2Rα with low affinity, to IL-2Rβ and IL-2Rγ ...

Preclinical studies showed that the addition of IL-15 could improve the performance of CAR T cell-based immunotherapies.

The study reveals IL-15's role in enhancing GPC3 CAR T cell therapy, improving tumor targeting and T cell survival in ...

Researchers report results of the first-in-human phase 1 clinical trials of a novel immunotherapy approach for solid tumors ...