The hypothalamus consists of several nuclei that integrate peripheral signals, such as adiposity and caloric intake, to regulate important pathways within the CNS controlling food intake.

We report here that the delivery of leptin to the hypothalamus through intracranial ... of rAAV-leptin farther away from the target nuclei (IV and IM), in contrast to the case with IH injections.

The hypothalamus in the brain contains the temperature monitoring centre for the body. The hypothalamus receives nerve impulses from structures in the skin called thermoreceptors, which give ...

and arcuate hypothalamic nuclei. 4,5 These ghrelin-containing neurons send efferent fibers to neurons that contain neuropeptide Y (NPY) and agouti-related protein (AgRP)—NPY/AgRP neurons—and ...

There are projections from the ARC to other hypothalamic nuclei, as well as the cerebral cortex and reward pathways. Multiple neuropeptides have been identified that appear to modulate pathways ...