TROP2 expression in small bowel adenocarcinoma: A potential target for novel therapeutic strategies. This is an ASCO Meeting Abstract from the 2025 ASCO Gastrointestinal Cancers Symposium. This ...

Sensitive tissue-based detection of AR-V7 and other androgen receptor alterations using combined DNA/RNA comprehensive genomic profiling.

Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...

Elliott B, Richardson C, Winderbaum J, Nickoloff JA, Jasin M. 1998 Gene conversion tracts from double-strand break repair in mammalian cells in mammalian cells. Mol Cell Biol. 1998;18:93-101. Johnson ...

LAE120 is a novel, allosteric and highly potent USP1 inhibitor, displaying monotherapy potency and combination activity with ...

Clinical relevance evaluation of a novel homologous recombination deficiency CE-IVD decentralized solution that identifies ovarian cancer patients that could potentially benefit from PARP-inhibitors.

"The association of homologous recombination repair defects with ... the stratification of patients with cancer associated with deficiency in this DNA damage repair (DDR) pathway.

"A key objective of research focused on early-stage breast cancer is to identify biomarkers that can select patients who might benefit from less aggressive treatments than chemotherapy and ...