GlobalData’s report assesses the drugs in the Histone Deacetylase 6 pipeline by therapy areas, indications, stages, MoA, RoA, molecule type and the key players in the development pipeline.

Drugs aimed at histone modifications are called histone deacetylase (HDAC) inhibitors. HDACs are enzymes that remove the acetyl groups from DNA, which condenses chromatin and stops transcription.

近期，中国科学院广州生物医药与健康研究院与澳门大学合作发表研究论文Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex（组蛋白去乙酰化酶Rpd3S核小体去乙酰化和DNA linker收紧的分子机制），被Cell ...

Miralinc Pharma Inc. has patented new heterocyclic selective histone deacetylase 6 (HDAC6) inhibitors reported to be useful for the treatment of type 2 Charcot-Marie-Tooth disease and ...

It has been shown that DNA methylation and histone deacetylation at the FLI1gene contribute to the profibrotic phenotype of SSc fibroblasts. Epigenetic modifications work in concert with other ...

Researchers from Ajou University presented data from a preclinical study that aimed to assess the potential of using the histone deacetylase (HDAC) inhibitor LMK-235 for the prevention of diabetic ...

The basic organizational unit of the genome is a nucleosome, which is a short segment of DNA wound around a complex of eight histone subunits. Each of these histones has a tail region which can be ...

After profiling hundreds of histone modifications in the NAc of stress-exposed mice, the researchers used a technique known as CUT & RUN (cleavage under targets and release using nuclease) to ...

Givinostat is a histone deacetylase (HDAC) inhibitor that works on pathogenic processes resulting from the dystrophin ...

This work presents a valuable finding on how the interplay between transcription factors SOX2 and OCT4 establishes the pluripotency network in early mouse embryos. Despite the high quality of the data ...