The paradigm of stellate cell activation provides an important ... The most effective way to eliminate hepatic fibrosis is to clear the primary cause of liver disease. The latter includes ...

Liver fibrosis is a progressive and potentially reversible condition that results from chronic liver damage, which can be ...

Learn about HMGB1's crucial role in liver diseases, its pathways and therapeutic potential that can treat liver diseases.

The HepaStem cells have immunomodulatory properties, similar to other MSCs, and act on the hepatic stellate cells that drive hepatic fibrosis. These immunomodulatory, antifibrotic, and liver ...

P62 and NBR1 are yin and yang. In contrast to NBR1, if p62 is high in hepatic stellate cells, a patient is protected from cancer, but if it is low, the immune system is knocked down. If NBR1 is ...

Carisma Therapeutics Inc. (CARM) presented promising preclinical data on engineered macrophages for treating liver fibrosis at the ...

The two other genes, MAT2A and MAT2B, are active within a second kind of liver cell called stellate cells, which also play a ...

The liver is largely comprised of hepatocytes, but Kupffer cells, endothelial cells and hepatic stellate cells are also present. Long-term machine perfusion holds great promise in the field of ...

2017 Exosome mediated intercellular communication between hepatitis C virus infected hepatocytes and hepatic stellate cells. J Virol. 91(6). pii: e02225-16. PMCID: PMC28077652 Sasaki R, Devhare PB, ...

SAN DIEGO, Oct. 22, 2024 (GLOBE NEWSWIRE) -- (“Gyre”) (Nasdaq: GYRE), a self-sustainable, commercial-stage biotechnology company with clinical development programs focusing on a variety of chronic ...

Activation of hepatic stellate cells is the central event in hepatic fibrosis. These perisinusoidal cells orchestrate an array of changes including degradation of the normal ECM of liver ...