Through the deal, Celgene gains Gloucester's romidepsin (Istodax), a histone deacetylase (HDAC) inhibitor, which was approved by the FDA in November 2009 to treat cutaneous T cell lymphoma (CTCL ...

Concerns about HA-based HDAC inhibitors such as genotoxicity, rapid clearance and extensive metabolite formation, led CKD’s research team to identify a series of NHA molecules that selectively ...

Italfarmaco's marketing application for HDAC inhibitor givinostat as a treatment for Duchenne muscular dystrophy (DMD) has been accepted by the EMA, setting up an approval decision in 2024.

In contrast, in the new trial combining an HDAC inhibitor with the immunotherapy, 3 of 27 patients had deep tumor shrinkage ...

"Our research has found that high HDAC6 levels lower the amount of progesterone receptors, making breast cancer cells less ...

reversible LSD1 inhibitor for acute myeloid leukaemia Session Title: Epigenetic modulators (HDAC bromodomain modulators, EZH2) Catalog Number: 250 Poster Board Number: PB238 Date/Time: Thursday ...