New work shows that activation of the Ras guanine nucleotide exchange factor SOS is dependent upon the membrane density of phosphatidylinositol-4,5-bisphosphate (PIP 2) and GTP-bound Ras.

Memorial Sloan Kettering Cancer Center-led researchers have identified a small molecule called gliocidin that kills ...

Gliocidin selectively kills glioblastoma cells by inhibiting nucleotide synthesis, showing potential as a therapeutic option ...

SOS1 is a guanine nucleotide exchange factor (GEF) that activates KRAS, and recent preclinical studies have demonstrated that combining KRAS and EGFR inhibitors with SOS1 inhibitors can overcome ...

A sugar molecule, a base, and a phosphate molecule group together to make up a nucleotide ... Cytosine (C) will "pair" to guanine (G), and adenine (A) will "pair" to thymine (T).