In addition to consensus sequences at their splice sites, eukaryotic genes with long introns also contain exonic splicing enhancers (ESEs). These sequences, which help position the splicing ...

Individual genes express multiple mRNAs by pre-mRNA alternative splicing, alternative polyadenylation or use of alternative promoters (first exons). As a result, individual genes express multiple ...

In a recent article, he showed that when genes are preferentially positioned near speckles, mRNA splicing is significantly more efficient ... critically integrated processes is achieved through ...

Illustration of a gene within a DNA sequence, showing the organization from chromosome to DNA double helix ... which are removed during the process of RNA splicing before the gene is translated into a ...

A breakthrough tool called Helicase-Assisted Continuous Editing (HACE) allows scientists to create precise genetic mutations ...

Alternative splicing is crucial for eukaryotic gene expression and influences protein function and regulation, with mis-splicing linked to numerous diseases. In this webinar, Dr. Megan L Noonan will ...

During splicing, non-coding segments of RNA ... busy post-production set in film or television, where genetic messages transcribed from DNA are assembled like raw footage. "You have many dozens ...

mRNA splicing is a fundamental part of the process that occurs when encoded DNA instructions are turned into a functional protein. After a gene is transcribed from DNA to RNA, extraneous sections ...

Gene mutations have consequences both good and bad—from resistance to conditions like diabetes to susceptibility to certain ...

The study, "Global impact of unproductive splicing on human gene expression levels and traits," was supported by funding from the National Institutes of Health (grants R01GM130738, R01HG011067 ...