Four studies examine this question, delving deeply into the role of the transcription factor Foxp3 in governing Treg differentiation and function. Tregs play essential roles in immune homeostasis ...

Led by Dr. Donald Kohn and Katelyn Masiuk, the researchers engineered a 'viral vector' that would turn on the FoxP3 gene only in regulatory T cells -- and not in other types of cells. Disclaimer ...

Raldh2, encoded by the Aldh1a2 gene, is expressed in intestinal dendritic ... RA drives the development of Tregs by activating Forkhead box P3 (Foxp3), the master transcription factor for Treg ...