Folate, also known as vitamin B9 or folic acid, is an essential nutrient for the human body. Many foods naturally contain folate, such as dark-green leafy vegetables, beans, whole grains, and eggs ...

Slow transport via folate receptor (lower affinity for methotrexate ... increased expression or activity of folylpolyglutamate hydrolase protein, polymorphic variants) Altered target enzymes ...