The severity of skin reactions to the treatment of actinic keratosis with 5-fluorouracil cream 4% was associated with a higher lesion clearance rate.

(2004) Prospective, multicenter, DB, RCT examining 0.5% 5-FU (Carac) once daily vs vehicle cream once daily for ... highlighted the importance of topical 5-fluorouracil in treatment of the lesions.

In clinical practice, the condition of these patients and the presence of AKs may warrant topical ... 5-fluorouracil; AK: Actinic keratosis; DB: Double-blinded; FC: 5-fluorouracil cream; RCT ...

One promising approach is topical immunotherapy with calcipotriol plus 5-fluorouracil (5-FU), which effectively eliminates precancerous skin lesions. A recent study published in the Journal of ...